| First Author | Kim EH | Year | 2016 |
| Journal | Virology | Volume | 490 |
| Pages | 75-82 | PubMed ID | 26855329 |
| Mgi Jnum | J:319171 | Mgi Id | MGI:6862994 |
| Doi | 10.1016/j.virol.2016.01.008 | Citation | Kim EH, et al. (2016) Mcl-1 regulates effector and memory CD8 T-cell differentiation during acute viral infection. Virology 490:75-82 |
| abstractText | Mcl-1, an anti-apoptotic member of Bcl-2 family maintains cell viability during clonal expansion of CD8 T cells, but the cell intrinsic role of Mcl-1 in contraction of effectors or the number of memory CD8 T cells is unknown. Mcl-1 levels decline during the contraction phase but rebound to high levels in memory CD8 T cells. Therefore, by overexpressing Mcl-1 in CD8 T cells we asked whether limiting levels of Mcl-1 promote contraction of effectors and constrain CD8 T-cell memory. Mcl-1 overexpression failed to affect CD8 T-cell expansion, contraction or the magnitude of CD8 T-cell memory. Strikingly, high Mcl-1 levels enhanced mTOR phosphorylation and augmented the differentiation of terminal effector cells and effector memory CD8 T cells to the detriment of poly-cytokine-producing central memory CD8 T cells. Taken together, these findings provided unexpected insights into the role of Mcl-1 in the differentiation of effector and memory CD8 T cells. |
