| First Author | Subbarayal B | Year | 2016 |
| Journal | J Immunol | Volume | 197 |
| Issue | 9 | Pages | 3464-3470 |
| PubMed ID | 27655846 | Mgi Jnum | J:319215 |
| Mgi Id | MGI:6863183 | Doi | 10.4049/jimmunol.1502641 |
| Citation | Subbarayal B, et al. (2016) IL-17 Augments B Cell Activation in Ocular Surface Autoimmunity. J Immunol 197(9):3464-3470 |
| abstractText | Accumulating evidence shows that IL-17 is critically involved in diverse autoimmune diseases. However, its effect on the induction and progression of the humoral immune response is not fully understood. Using a preclinical model of IL-17-mediated dry eye disease, we demonstrate that upon encountering both the BCR and a secondary T cell signal, IL-17 can enhance B cell proliferation and germinal center formation in dry eye disease mice, suggesting that a stable Ag-dependent T-B cell interaction is required. Additionally, IL-17 also promotes the differentiation of B cells into isotype-switched B cells and plasma cells. Furthermore, we show that Th17 cells are more effective than Th1 cells to provide B cell help. Reduced B cell response correlates with significant reduction in clinical disease after in vivo IL-17A neutralization. In conclusion, our findings demonstrate a new role of IL-17 in promoting autoimmunity in part through directly enhancing B cell proliferation, differentiation, and plasma cell generation. |
