| First Author | López-Yglesias AH | Year | 2021 |
| Journal | PLoS Pathog | Volume | 17 |
| Issue | 1 | Pages | e1008299 |
| PubMed ID | 33465134 | Mgi Jnum | J:325240 |
| Mgi Id | MGI:6804891 | Doi | 10.1371/journal.ppat.1008299 |
| Citation | Lopez-Yglesias AH, et al. (2021) T-bet-dependent ILC1- and NK cell-derived IFN-gamma mediates cDC1-dependent host resistance against Toxoplasma gondii. PLoS Pathog 17(1):e1008299 |
| abstractText | Host resistance against intracellular pathogens requires a rapid IFN-gamma mediated immune response. We reveal that T-bet-dependent production of IFN-gamma is essential for the maintenance of inflammatory DCs at the site of infection with a common protozoan parasite, Toxoplasma gondii. A detailed analysis of the cellular sources for T-bet-dependent IFN-gamma identified that ILC1s and to a lesser degree NK, but not TH1 cells, were involved in the regulation of inflammatory DCs via IFN-gamma. Mechanistically, we established that T-bet dependent innate IFN-gamma is critical for the induction of IRF8, an essential transcription factor for cDC1s. Failure to upregulate IRF8 in DCs resulted in acute susceptibility to T. gondii infection. Our data identifies that T-bet dependent production of IFN-gamma by ILC1 and NK cells is indispensable for host resistance against intracellular infection via maintaining IRF8+ inflammatory DCs at the site of infection. |
