| First Author | Russler-Germain EV | Year | 2021 |
| Journal | Elife | Volume | 10 |
| PubMed ID | 33533717 | Mgi Jnum | J:325241 |
| Mgi Id | MGI:6805013 | Doi | 10.7554/eLife.54792 |
| Citation | Russler-Germain EV, et al. (2021) Gut Helicobacter presentation by multiple dendritic cell subsets enables context-specific regulatory T cell generation. Elife 10:e54792 |
| abstractText | Generation of tolerogenic peripheral regulatory T (pTreg) cells is commonly thought to involve CD103(+) gut dendritic cells (DCs), yet their role in commensal-reactive pTreg development is unclear. Using two Helicobacter-specific T cell receptor (TCR) transgenic mouse lines, we found that both CD103(+) and CD103(-) migratory, but not resident, DCs from the colon-draining mesenteric lymph node presented Helicobacter antigens to T cells ex vivo. Loss of most CD103(+) migratory DCs in vivo using murine genetic models did not affect the frequency of Helicobacter-specific pTreg cell generation or induce compensatory tolerogenic changes in the remaining CD103(-) DCs. By contrast, activation in a Th1-promoting niche in vivo blocked Helicobacter-specific pTreg generation. Thus, these data suggest a model where DC-mediated effector T cell differentiation is 'dominant', necessitating that all DC subsets presenting antigen are permissive for pTreg cell induction to maintain gut tolerance. |
