| First Author | Guner G | Year | 2017 |
| Journal | eNeuro | Volume | 4 |
| Issue | 1 | PubMed ID | 28303257 |
| Mgi Jnum | J:317560 | Mgi Id | MGI:6856162 |
| Doi | 10.1523/ENEURO.0255-16.2017 | Citation | Guner G, et al. (2017) NEUROD2 Regulates Stim1 Expression and Store-Operated Calcium Entry in Cortical Neurons. eNeuro 4(1):ENEURO.0255-16.2017 |
| abstractText | Calcium signaling controls many key processes in neurons, including gene expression, axon guidance, and synaptic plasticity. In contrast to calcium influx through voltage- or neurotransmitter-gated channels, regulatory pathways that control store-operated calcium entry (SOCE) in neurons are poorly understood. Here, we report a transcriptional control of Stim1 (stromal interaction molecule 1) gene, which is a major sensor of endoplasmic reticulum (ER) calcium levels and a regulator of SOCE. By using a genome-wide chromatin immunoprecipitation and sequencing approach in mice, we find that NEUROD2, a neurogenic transcription factor, binds to an intronic element within the Stim1 gene. We show that NEUROD2 limits Stim1 expression in cortical neurons and consequently fine-tunes the SOCE response upon depletion of ER calcium. Our findings reveal a novel mechanism that regulates neuronal calcium homeostasis during cortical development. |
