| First Author | Phares TW | Year | 2013 |
| Journal | J Neuroimmunol | Volume | 263 |
| Issue | 1-2 | Pages | 43-54 |
| PubMed ID | 23992866 | Mgi Jnum | J:318137 |
| Mgi Id | MGI:6858392 | Doi | 10.1016/j.jneuroim.2013.07.019 |
| Citation | Phares TW, et al. (2013) IL-21 optimizes T cell and humoral responses in the central nervous system during viral encephalitis. J Neuroimmunol 263(1-2):43-54 |
| abstractText | Acute coronavirus encephalomyelitis is controlled by T cells while humoral responses suppress virus persistence. This study defines the contribution of interleukin (IL)-21, a regulator of T and B cell function, to central nervous system (CNS) immunity. IL-21 receptor deficiency did not affect peripheral T cell activation or trafficking, but dampened granzyme B, gamma interferon and IL-10 expression by CNS T cells and reduced serum and intrathecal humoral responses. Viral control was already lost prior to humoral CNS responses, but demyelination remained comparable. These data demonstrate a critical role of IL-21 in regulating CNS immunity, sustaining viral persistence and preventing mortality. |
