| First Author | Ishii H | Year | 2013 |
| Journal | Cell Death Dis | Volume | 4 |
| Pages | e710 | PubMed ID | 23828573 |
| Mgi Jnum | J:318183 | Mgi Id | MGI:6858639 |
| Doi | 10.1038/cddis.2013.234 | Citation | Ishii H, et al. (2013) ifn-gamma-dependent secretion of IL-10 from Th1 cells and microglia/macrophages contributes to functional recovery after spinal cord injury. Cell Death Dis 4:e710 |
| abstractText | Transfer of type-1 helper T-conditioned (Th1-conditioned) cells promotes functional recovery with enhanced axonal remodeling after spinal cord injury (SCI). This study explored the molecular mechanisms underlying the beneficial effects of pro-inflammatory Th1-conditioned cells after SCI. The effect of Th1-conditioned cells from interferon-gamma (ifn-gamma) knockout mice (ifn-gamma(-/-) Th1 cells) on the recovery after SCI was reduced. Transfer of Th1-conditioned cells led to the activation of microglia (MG) and macrophages (MPhis), with interleukin 10 (IL-10) upregulation. This upregulation of IL-10 was reduced when ifn-gamma(-/-) Th1 cells were transferred. Intrathecal neutralization of IL-10 in the spinal cord attenuated the effects of Th1-conditioned cells. Further, IL-10 is robustly secreted from Th1-conditioned cells in an ifn-gamma-dependent manner. Th1-conditioned cells from interleukin 10 knockout (il-10(-/-)) mice had no effects on recovery from SCI. These findings demonstrate that ifn-gamma-dependent secretion of IL-10 from Th1 cells, as well as native MG/MPhis, is required for the promotion of motor recovery after SCI. |
