| First Author | Visperas A | Year | 2014 |
| Journal | Mucosal Immunol | Volume | 7 |
| Issue | 3 | Pages | 625-33 |
| PubMed ID | 24129161 | Mgi Jnum | J:318207 |
| Mgi Id | MGI:6858756 | Doi | 10.1038/mi.2013.82 |
| Citation | Visperas A, et al. (2014) IL-27, targeting antigen-presenting cells, promotes Th17 differentiation and colitis in mice. Mucosal Immunol 7(3):625-33 |
| abstractText | T helper type 17 (Th17) cells have been implicated in autoimmunity and inflammatory bowel disease (IBD). Antigen-presenting cell (APC) -derived cytokines such as interleukin (IL)-1beta and IL-6 are key mediators supporting Th17 differentiation, yet how these factors are induced in vivo remains unclear. Here, we show that IL-27 acting on APCs enhances IL-6 and IL-1beta production and Th17 differentiation. IL-27Ralpha-/- T-cell receptor (TCR)beta-/- recipients fail to develop gut inflammation following naive CD4 T-cell transfer, whereas IL-27Ralpha+/+ TCRbeta-/- recipients develop severe colitis. Investigation of T-cell responses exhibits that IL-27Ralpha-/- TCRbeta-/- mice do not support Th17 differentiation with significantly decreased levels of IL-6 and IL-1beta by APCs. Our study has identified a novel proinflammatory role for IL-27 in vivo that promotes Th17 differentiation by inducing Th17-supporting cytokines in APCs. |
