| First Author | Yamashita-Kanemaru Y | Year | 2015 |
| Journal | J Immunol | Volume | 194 |
| Issue | 12 | Pages | 5644-53 |
| PubMed ID | 25972481 | Mgi Jnum | J:323841 |
| Mgi Id | MGI:6858996 | Doi | 10.4049/jimmunol.1401942 |
| Citation | Yamashita-Kanemaru Y, et al. (2015) CD155 (PVR/Necl5) mediates a costimulatory signal in CD4+ T cells and regulates allergic inflammation. J Immunol 194(12):5644-53 |
| abstractText | Although Th1 and Th2 cells are known to be involved in allergic inflammatory diseases, the molecular mechanisms underlying their differentiation are incompletely understood. In this study, we identified CD155 as a costimulatory molecule on CD4(+) T cells. Importantly, CD155-mediated signaling induced Th1 development in both humans and mice, as evidenced by production of IFN-gamma and upregulation of Tbx21 transcription; these effects were independent of IL-12 but dependent on NF-kappaB-induced autocrine IFN-gamma that triggered positive feedback via STAT1 activation. Mice genetically deficient in CD155 or treated with anti-CD155 Ab exhibited attenuated Th1-type contact hypersensitivity. Thus, CD155 plays an important regulatory role in helper T cell differentiation and allergic diseases. |
