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Publication : BDNF activates an NFI-dependent neurodevelopmental timing program by sequestering NFATc4.

First Author  Ding B Year  2018
Journal  Mol Biol Cell Volume  29
Issue  8 Pages  975-987
PubMed ID  29467254 Mgi Jnum  J:318500
Mgi Id  MGI:6859905 Doi  10.1091/mbc.E16-08-0595
Citation  Ding B, et al. (2018) BDNF activates an NFI-dependent neurodevelopmental timing program by sequestering NFATc4. Mol Biol Cell 29(8):975-987
abstractText  We show that BDNF regulates the timing of neurodevelopment via a novel mechanism of extranuclear sequestration of NFATc4 in Golgi. This leads to accelerated derepression of an NFI temporal occupancy gene program in cerebellar granule cells that includes Bdnf itself, revealing an autoregulatory loop within the program driven by BDNF and NFATc4.
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