| First Author | Saitoh Y | Year | 2019 |
| Journal | Histochem Cell Biol | Volume | 151 |
| Issue | 5 | Pages | 385-394 |
| PubMed ID | 30357511 | Mgi Jnum | J:324872 |
| Mgi Id | MGI:6860051 | Doi | 10.1007/s00418-018-1745-y |
| Citation | Saitoh Y, et al. (2019) The membrane palmitoylated protein, MPP6, is involved in myelin formation in the mouse peripheral nervous system. Histochem Cell Biol 151(5):385-394 |
| abstractText | A membrane skeletal molecular complex, protein 4.1G-membrane palmitoylated protein 6 (MPP6)-Lin7-cell adhesion molecule 4 (CADM4), is incorporated in Schwann cells, especially in Schmidt-Lanterman incisures (SLIs), in the mouse peripheral nervous system (PNS). MPP6, Lin7, and CADM4 are transported to SLIs by 4.1G. In this study, we created MPP6-deficient mice and evaluated myelin structure and MPP6 protein complexes. In SLIs in MPP6-deficient nerves, Lin7 was rarely detected by immunohistochemistry and western blotting, but the localization and amount of CADM4 and 4.1G were not altered. Motor activity was not significantly impaired in a tail-suspension test, but the sciatic nerves of MPP6-deficient mice had thicker myelin in internodes by electron microscopy compared to that of wild-type mice. These results indicate that the MPP6-Lin7 complex regulates myelin formation. |
