| First Author | Firmino-Cruz L | Year | 2018 |
| Journal | Cell Immunol | Volume | 334 |
| Pages | 20-30 | PubMed ID | 30170688 |
| Mgi Jnum | J:318539 | Mgi Id | MGI:6860061 |
| Doi | 10.1016/j.cellimm.2018.08.014 | Citation | Firmino-Cruz L, et al. (2018) Immunomodulating role of IL-10-producing B cells in Leishmania amazonensis infection. Cell Immunol 334:20-30 |
| abstractText | This work aims to study the immunomodulation of B lymphocytes during L. amazonensis infection. We demonstrated in this study that follicular B cells from draining lymph nodes of infected wild type BALB/c mice are the major source of IL-10 during infection. We infected BALB/Xid mice that developed smaller lesions in comparison with the control, but the parasite load obtained from the infected tissues was similar in both groups. We observed a reduction in the number of follicular B cells from BALB/Xid mice in relation to WT mice and, consequently, lower levels of IgM, IgG, IgG1, IgG2a and IgG2b in the serum of BALB/Xid when compared with wild type mice. BALB/Xid mice also presented lower levels of IL-10 in the infected footpad, draining lymph nodes and in the spleen when compared with WT infected tissues. We did not detect differences in the number of IL-10 producing CD4(+) and CD8(+) T cells between WT and BALB/Xid mice; however, a strong reduction of IL-10 producing follicular B cells was noted in BALB/Xid mice. When analyzed together, our data indicate that B cells are related with lesion pathogenesis through the production of antibodies and IL-10. |
