| First Author | Nowyhed HN | Year | 2015 |
| Journal | J Immunol | Volume | 195 |
| Issue | 8 | Pages | 3515-9 |
| PubMed ID | 26363057 | Mgi Jnum | J:330994 |
| Mgi Id | MGI:6869155 | Doi | 10.4049/jimmunol.1403027 |
| Citation | Nowyhed HN, et al. (2015) Cutting Edge: The Orphan Nuclear Receptor Nr4a1 Regulates CD8+ T Cell Expansion and Effector Function through Direct Repression of Irf4. J Immunol 195(8):3515-9 |
| abstractText | The transcription factor IFN regulatory factor (IRF)4 was shown to play a crucial role in the protective CD8(+) T cell response; however, regulation of IRF4 expression in CD8(+) T cells remains unclear. In this article, we report a critical role for Nr4a1 in regulating the expansion, differentiation, and function of CD8(+) T cells through direct transcriptional repression of Irf4. Without Nr4a1, the regulation of IRF4 is lost, driving an increase in Irf4 expression and, in turn, resulting in a faster rate of CD8 T cell proliferation and expansion. Nr4a1-deficient mice show increases in CD8 T cell effector responses with improved clearance of Listeria monocytogenes. Our data support a novel and critical role for Nr4a1 in the regulation of CD8(+) T cell expansion and effector function through transcriptional repression of Irf4. |
