| First Author | Hirai-Yuki A | Year | 2016 |
| Journal | Science | Volume | 353 |
| Issue | 6307 | Pages | 1541-1545 |
| PubMed ID | 27633528 | Mgi Jnum | J:323366 |
| Mgi Id | MGI:6869427 | Doi | 10.1126/science.aaf8325 |
| Citation | Hirai-Yuki A, et al. (2016) MAVS-dependent host species range and pathogenicity of human hepatitis A virus. Science 353(6307):1541-1545 |
| abstractText | Hepatotropic viruses are important causes of human disease, but the intrahepatic immune response to hepatitis viruses is poorly understood because of a lack of tractable small- animal models. We describe a murine model of hepatitis A virus (HAV) infection that recapitulates critical features of type A hepatitis in humans. We demonstrate that the capacity of HAV to evade MAVS-mediated type I interferon responses defines its host species range. HAV-induced liver injury was associated with interferon-independent intrinsic hepatocellular apoptosis and hepatic inflammation that unexpectedly resulted from MAVS and IRF3/7 signaling. This murine model thus reveals a previously undefined link between innate immune responses to virus infection and acute liver injury, providing a new paradigm for viral pathogenesis in the liver. |
