| First Author | Schneider MR | Year | 2015 |
| Journal | Bioessays | Volume | 37 |
| Issue | 3 | Pages | 294-304 |
| PubMed ID | 25449798 | Mgi Jnum | J:320387 |
| Mgi Id | MGI:6871850 | Doi | 10.1002/bies.201400141 |
| Citation | Schneider MR, et al. (2015) E-cadherin's role in development, tissue homeostasis and disease: Insights from mouse models: Tissue-specific inactivation of the adhesion protein E-cadherin in mice reveals its functions in health and disease. Bioessays 37(3):294-304 |
| abstractText | Recent studies uncovered critical roles of the adhesion protein E-cadherin in health and disease. Global inactivation of Cdh1, the gene encoding E-cadherin in mice, results in early embryonic lethality due to an inability to form the trophectodermal epithelium. To unravel E-cadherin's functions beyond development, numerous mouse lines with tissue-specific disruption of Cdh1 have been generated. The consequences of E-cadherin loss showed great variability depending on the tissue in question, ranging from nearly undetectable changes to a complete loss of tissue structure and function. This review focuses on these studies and discusses how they provided important insights into E-cadherin's role in cell adhesion, proliferation and differentiation, and its consequences for biological processes as epithelial-to-mesenchymal transition, vascularization, and carcinogenesis. Lastly, we present some perspectives and possible approaches for future research. |
