| First Author | Kondo T | Year | 2011 |
| Journal | Med Mol Morphol | Volume | 44 |
| Issue | 4 | Pages | 221-7 |
| PubMed ID | 22179185 | Mgi Jnum | J:320709 |
| Mgi Id | MGI:6877287 | Doi | 10.1007/s00795-010-0531-2 |
| Citation | Kondo T, et al. (2011) An increase in apoptosis and reduction in alphaB-crystallin expression levels in the lens underlie the cataractogenesis of Morioka cataract (MCT) mice. Med Mol Morphol 44(4):221-7 |
| abstractText | We examined the morphological changes in fibers, localization of apoptotic cells, and protein expression of alphaB-crystallin in the lens of Morioka cataract (MCT) mice, a novel cataract model. Using a scanning electron microscope, swollen lens fibers and enlarged spaces between lens fibers were observed in the lens of 3-week-old MCT mice. At 2 weeks of age (before cataract), the single-strand DNA (ssDNA)-positive (indicating apoptosis) cell ratio of the lens epithelium was significantly higher in MCT than in wild-type ddY mice. At 2 and 4 weeks of age, alphaB-crystallin protein expression of the lens in MCT mice was significantly lower than that in wild-type ddY mice. These findings suggest that increase in apoptosis and reduction in alphaBcrystallin level are involved in the cataractogenesis of MCT mice. |
