| First Author | Paim LMG | Year | 2022 |
| Journal | Proc Natl Acad Sci U S A | Volume | 119 |
| Issue | 12 | Pages | e2119381119 |
| PubMed ID | 35294282 | Mgi Jnum | J:322445 |
| Mgi Id | MGI:7257746 | Doi | 10.1073/pnas.2119381119 |
| Citation | Paim LMG, et al. (2022) Cell size and polarization determine cytokinesis furrow ingression dynamics in mouse embryos. Proc Natl Acad Sci U S A 119(12):e2119381119 |
| abstractText | SignificanceThe final step of cell division, termed cytokinesis, comprises the constriction of a furrow that divides the cytoplasm to form two daughter cells. Although cytokinesis is well studied in traditional cell systems, how cytokinesis is regulated in complex multicellular settings and during cell-fate decisions is less well understood. Here, using live imaging and physical and molecular interventions, we find that the emergence of cell polarity during mouse embryo morphogenesis dramatically impacts cytokinesis mechanisms. Specifically, the assembly of the apical domain in outer cells locally inhibits the cytokinetic machinery, leading to an unexpected laterally biased cytokinesis. |
