| First Author | Fei L | Year | 2022 |
| Journal | Nat Genet | Volume | 54 |
| Issue | 7 | Pages | 1051-1061 |
| PubMed ID | 35817981 | Mgi Jnum | J:328715 |
| Mgi Id | MGI:7312213 | Doi | 10.1038/s41588-022-01118-8 |
| Citation | Fei L, et al. (2022) Systematic identification of cell-fate regulatory programs using a single-cell atlas of mouse development. Nat Genet 54(7):1051-1061 |
| abstractText | Waddington's epigenetic landscape is a metaphor frequently used to illustrate cell differentiation. Recent advances in single-cell genomics are altering our understanding of the Waddington landscape, yet the molecular mechanisms of cell-fate decisions remain poorly understood. We constructed a cell landscape of mouse lineage differentiation during development at the single-cell level and described both lineage-common and lineage-specific regulatory programs during cell-type maturation. We also found lineage-common regulatory programs that are broadly active during the development of invertebrates and vertebrates. In particular, we identified Xbp1 as an evolutionarily conserved regulator of cell-fate determinations across different species. We demonstrated that Xbp1 transcriptional regulation is important for the stabilization of the gene-regulatory networks for a wide range of mouse cell types. Our results offer genetic and molecular insights into cellular gene-regulatory programs and will serve as a basis for further advancing the understanding of cell-fate decisions. |
