| First Author | Melzer S | Year | 2021 |
| Journal | bioRxiv | Mgi Jnum | J:307666 |
| Mgi Id | MGI:6724061 | Doi | 10.1101/2020.10.26.355123 |
| Citation | Melzer S, et al. (2021) Bombesin-like peptide recruits disinhibitory cortical circuits and enhances fear memories. bioRxiv |
| abstractText | Disinhibitory neurons throughout the mammalian cortex are powerful enhancers of circuit excitability and plasticity. The differential expression of neuropeptide receptors in disinhibitory, inhibitory and excitatory neurons suggests that each circuit motif is controlled by distinct neuropeptidergic systems. Here, we reveal that a bombesin-like neuropeptide, gastrin-releasing peptide (GRP), recruits disinhibitory cortical microcircuits through selective targeting and activation of vasoactive intestinal peptide (VIP)-expressing cells. Using a newly-developed genetically-encoded GRP sensor and trans-synaptic tracing we reveal that GRP regulates VIP cells via extrasynaptic diffusion from several putative local and long-range sources. In vivophotometry and CRISPR/Cas9-mediated knockout of the GRP receptor (GRPR) in auditory cortex indicatr that VIP cells are strongly recruited by novel sounds and aversive shocks, and that GRP-GRPR signaling enhances auditory fear memories. Our data establish peptidergic recruitment of selective disinhibitory cortical microcircuits as a mechanism to regulate fear memories. |
