| First Author | Tang C | Year | 2023 |
| Journal | Nat Commun | Volume | 14 |
| Issue | 1 | Pages | 1493 |
| PubMed ID | 36932082 | Mgi Jnum | J:334292 |
| Mgi Id | MGI:7447851 | Doi | 10.1038/s41467-023-37229-x |
| Citation | Tang C, et al. (2023) Blocking Dectin-1 prevents colorectal tumorigenesis by suppressing prostaglandin E2 production in myeloid-derived suppressor cells and enhancing IL-22 binding protein expression. Nat Commun 14(1):1493 |
| abstractText | Dectin-1 (gene Clec7a), a receptor for beta-glucans, plays important roles in the host defense against fungi and immune homeostasis of the intestine. Although this molecule is also suggested to be involved in the regulation of tumorigenesis, the role in intestinal tumor development remains to be elucidated. In this study, we find that azoxymethane-dextran-sodium-sulfate-induced and Apc(Min)-induced intestinal tumorigenesis are suppressed in Clec7a(-/-) mice independently from commensal microbiota. Dectin-1 is preferentially expressed on myeloid-derived suppressor cells (MDSCs). In the Clec7a(-/-) mouse colon, the proportion of MDSCs and MDSC-derived prostaglandin E(2) (PGE(2)) levels are reduced, while the expression of IL-22 binding protein (IL-22BP; gene Il22ra2) is upregulated. Dectin-1 signaling induces PGE(2)-synthesizing enzymes and PGE(2) suppresses Il22ra2 expression in vitro and in vivo. Administration of short chain beta-glucan laminarin, an antagonist of Dectin-1, suppresses the development of mouse colorectal tumors. Furthermore, in patients with colorectal cancer (CRC), the expression of CLEC7A is also observed in MDSCs and correlated with the death rate and tumor severity. Dectin-1 signaling upregulates PGE(2)-synthesizing enzyme expression and PGE(2) suppresses IL22RA2 expression in human CRC-infiltrating cells. These observations indicate a role of the Dectin-1-PGE(2)-IL-22BP axis in regulating intestinal tumorigenesis, suggesting Dectin-1 as a potential target for CRC therapy. |
