| First Author | Wang JP | Year | 1998 |
| Journal | Biomed Res | Volume | 19 |
| Issue | 5 | Pages | 315-325 |
| Mgi Jnum | J:55945 | Mgi Id | MGI:1339810 |
| Doi | 10.2220/biomedres.19.315 | Citation | Wang JP, et al. (1998) Expression of Src family during development of the mouse nervous system. Biomed Res 19(5):315-325 |
| abstractText | This work provides insight the function of Src proto- oncogene in neurogenesis by immunohisto- chemically investigating the distribution and time course of development of 8 src-related protein- tyrosine kinases (c- Src, Fyn, Yes, Lyn, Lck, Hck, Fgr, Blk) in vivo in the developing nervous system of a mouse. Experimental results indicate that all members of Src family are expressed early in dividing cells in the neural plate by embryonic day 8 and, then, maintained in the central and peripheral nervous system until late prenatal stages. The immunoreactivity is widely distributed not only in the brain and spinal cord, but also in neural crest-derived structures, including spinal and sympathetic ganglia. Src- positive structures found in the fetal brain are primarily located in the forebrain and diencephalon. In addition, high levels of immunoreactivity can be observed in special sensory organs such as the retina and otic vesicle. Although various members closely resemble each other in terms of the overall pattern of immunoreactivity, implying an overlapping functional aspects of different members of the family, a slight difference arises in the time course of expression and staining intensity. Moreover, the early appearance, high levels and wide distribution of individual members of the Src family in the mouse's nervous system suggest that these gene products profoundly influence neuronal differentiation and maturation. |
