| First Author | Kumar M | Year | 2023 |
| Journal | Nat Commun | Volume | 14 |
| Issue | 1 | Pages | 4170 |
| PubMed ID | 37443148 | Mgi Jnum | J:342554 |
| Mgi Id | MGI:7508470 | Doi | 10.1038/s41467-023-39732-7 |
| Citation | Kumar M, et al. (2023) Cell-type-specific plasticity of inhibitory interneurons in the rehabilitation of auditory cortex after peripheral damage. Nat Commun 14(1):4170 |
| abstractText | Peripheral sensory organ damage leads to compensatory cortical plasticity that is associated with a remarkable recovery of cortical responses to sound. The precise mechanisms that explain how this plasticity is implemented and distributed over a diverse collection of excitatory and inhibitory cortical neurons remain unknown. After noise trauma and persistent peripheral deficits, we found recovered sound-evoked activity in mouse A1 excitatory principal neurons (PNs), parvalbumin- and vasoactive intestinal peptide-expressing neurons (PVs and VIPs), but reduced activity in somatostatin-expressing neurons (SOMs). This cell-type-specific recovery was also associated with cell-type-specific intrinsic plasticity. These findings, along with our computational modelling results, are consistent with the notion that PV plasticity contributes to PN stability, SOM plasticity allows for increased PN and PV activity, and VIP plasticity enables PN and PV recovery by inhibiting SOMs. |
