| First Author | Feng Y | Year | 2023 |
| Journal | Cell Rep | Volume | 42 |
| Issue | 10 | Pages | 113313 |
| PubMed ID | 37858461 | Mgi Jnum | J:342556 |
| Mgi Id | MGI:7546684 | Doi | 10.1016/j.celrep.2023.113313 |
| Citation | Feng Y, et al. (2023) Stress regulates Alzheimer's disease progression via selective enrichment of CD8(+) T cells. Cell Rep 42(10):113313 |
| abstractText | This study investigates stress's impact on Alzheimer's disease (AD) using male APP/PS1 transgenic mice. Negative stressors (chronic social defeat, restraint) and positive hedonia (environmental enrichment, EE) were applied. Stress worsens AD pathology, while EE slows progression. Brain RNA sequencing reveals interleukin-6 (IL-6) and IL-10 as key stress-related AD regulators. Flow cytometry shows that the CD8(+)/CD4(+) T cell ratio shifts in response to stress exposure and EE. Stress exposure increases CD8(+)/CD4(+) ratio, opposite to EE. Depletion and enrichment of CD8(+) T cells both accelerate AD, indicating immune intervention's negative impact. Stress management and balanced immunity may aid AD therapy, highlighting novel potential treatment. |
