| First Author | Willows JW | Year | 2024 |
| Journal | Neurobiol Aging | Volume | 136 |
| Pages | 58-69 | PubMed ID | 38325031 |
| Mgi Jnum | J:345808 | Mgi Id | MGI:7611568 |
| Doi | 10.1016/j.neurobiolaging.2024.01.010 | Citation | Willows JW, et al. (2024) Contributions of mouse genetic strain background to age-related phenotypes in physically active HET3 mice. Neurobiol Aging 136:58-69 |
| abstractText | We assessed aging hallmarks in skin, muscle, and adipose in the genetically diverse HET3 mouse, and generated a broad dataset comparing these to individual animal diagnostic SNPs from the 4 founding inbred strains of the HET3 line. For middle- and old-aged HET3 mice, we provided running wheel exercise to ensure our observations were not purely representative of sedentary animals, but age-related phenotypes were not improved with running wheel activity. Adipose tissue fibrosis, peripheral neuropathy, and loss of neuromuscular junction integrity were consistent phenotypes in older-aged HET3 mice regardless of physical activity, but aspects of these phenotypes were moderated by the SNP% contributions of the founding strains for the HET3 line. Taken together, the genetic contribution of founder strain SNPs moderated age-related phenotypes in skin and muscle innervation and were dependent on biological sex and chronological age. However, there was not a single founder strain (BALB/cJ, C57BL/6J, C3H/HeJ, DBA/2J) that appeared to drive more protection or disease-risk across aging in this mouse line, but genetic diversity in general was more protective. |
