| First Author | Ponnusamy T | Year | 2024 |
| Journal | Mitochondrion | Volume | 76 |
| Pages | 101877 | PubMed ID | 38599304 |
| Mgi Jnum | J:350505 | Mgi Id | MGI:7663028 |
| Doi | 10.1016/j.mito.2024.101877 | Citation | Ponnusamy T, et al. (2024) Mrs2-mediated mitochondrial magnesium uptake is essential for the regulation of MCU-mediated mitochondrial Ca(2+) uptake and viability. Mitochondrion 76:101877 |
| abstractText | Mitochondrial Ca(2+) uptake is essential in regulating bioenergetics, cell death, and cytosolic Ca(2+) transients. Mitochondrial Calcium Uniporter (MCU) mediates the mitochondrial Ca(2+) uptake. Though MCU regulation by MICUs is unequivocally established, there needs to be more knowledge of whether divalent cations regulate MCU. Here, we set out to understand the mitochondrial matrix Mg(2+)-dependent regulation of MCU activity. We showed that decreased matrix [Mg(2+)] is associated with increased MCU activity and significantly prompted mitochondrial permeability transition pore opening. Our findings support the critical role of mMg(2+) in regulating MCU activity. |
