| First Author | Frolova VS | Year | 2024 |
| Journal | Int J Mol Sci | Volume | 25 |
| Issue | 23 | PubMed ID | 39684667 |
| Mgi Jnum | J:359837 | Mgi Id | MGI:7789709 |
| Doi | 10.3390/ijms252312954 | Citation | Frolova VS, et al. (2024) Serotonin Signaling in Mouse Preimplantation Development: Insights from Transcriptomic and Structural-Functional Analyses. Int J Mol Sci 25(23) |
| abstractText | Serotonin (5-HT), a versatile signaling molecule, plays a variety of roles in both neurotransmission and tissue regulation. The influence of serotonin on early development was first studied in marine invertebrate embryos and has since been documented in a variety of vertebrate species, including mammals. The present study investigates the expression and functional activity of serotonin components in mouse embryos, focusing on key receptors and transporters. Transcriptomic analyses revealed that mRNA transcripts related to serotonin show marked expression during the oogenesis and preimplantation stages. The results of the immunohistochemical studies show the presence of serotonin, the vesicular monoamine transporter VMAT2, and several membrane receptors (5-HT(1B), 5-HT(1D), 5-HT(2B), 5-HT(7)) in the early stages of development. A functional analysis performed with the VMAT inhibitor reserpine revealed the crucial role of vesicular transport in the maintenance of serotonin signaling. The findings presented here support the hypothesis that serotonin plays a significant role in oocyte maturation and embryonic development, as well as in interblastomere interactions. |
