| First Author | Vickovic S | Year | 2019 |
| Journal | Nat Methods | Volume | 16 |
| Issue | 10 | Pages | 987-990 |
| PubMed ID | 31501547 | Mgi Jnum | J:356082 |
| Mgi Id | MGI:7762174 | Doi | 10.1038/s41592-019-0548-y |
| Citation | Vickovic S, et al. (2019) High-definition spatial transcriptomics for in situ tissue profiling. Nat Methods 16(10):987-990 |
| abstractText | Spatial and molecular characteristics determine tissue function, yet high-resolution methods to capture both concurrently are lacking. Here, we developed high-definition spatial transcriptomics, which captures RNA from histological tissue sections on a dense, spatially barcoded bead array. Each experiment recovers several hundred thousand transcript-coupled spatial barcodes at 2-mum resolution, as demonstrated in mouse brain and primary breast cancer. This opens the way to high-resolution spatial analysis of cells and tissues. |
