| First Author | Macaulay IC | Year | 2015 |
| Journal | Nat Methods | Volume | 12 |
| Issue | 6 | Pages | 519-22 |
| PubMed ID | 25915121 | Mgi Jnum | J:356567 |
| Mgi Id | MGI:7762659 | Doi | 10.1038/nmeth.3370 |
| Citation | Macaulay IC, et al. (2015) G&T-seq: parallel sequencing of single-cell genomes and transcriptomes. Nat Methods 12(6):519-22 |
| abstractText | The simultaneous sequencing of a single cell's genome and transcriptome offers a powerful means to dissect genetic variation and its effect on gene expression. Here we describe G&T-seq, a method for separating and sequencing genomic DNA and full-length mRNA from single cells. By applying G&T-seq to over 220 single cells from mice and humans, we discovered cellular properties that could not be inferred from DNA or RNA sequencing alone. |
