| First Author | Fesneau O | Year | 2024 |
| Journal | Nat Immunol | Volume | 25 |
| Issue | 9 | Pages | 1637-1649 |
| PubMed ID | 39060651 | Mgi Jnum | J:361565 |
| Mgi Id | MGI:7859593 | Doi | 10.1038/s41590-024-01909-7 |
| Citation | Fesneau O, et al. (2024) An intestinal T(H)17 cell-derived subset can initiate cancer. Nat Immunol 25(9):1637-1649 |
| abstractText | Approximately 25% of cancers are preceded by chronic inflammation that occurs at the site of tumor development. However, whether this multifactorial oncogenic process, which commonly occurs in the intestines, can be initiated by a specific immune cell population is unclear. Here, we show that an intestinal T cell subset, derived from interleukin-17 (IL-17)-producing helper T (T(H)17) cells, induces the spontaneous transformation of the intestinal epithelium. This subset produces inflammatory cytokines, and its tumorigenic potential is not dependent on IL-17 production but on the transcription factors KLF6 and T-BET and interferon-gamma. The development of this cell type is inhibited by transforming growth factor-beta1 (TGFbeta1) produced by intestinal epithelial cells. TGFbeta signaling acts on the pretumorigenic T(H)17 cell subset, preventing its progression to the tumorigenic stage by inhibiting KLF6-dependent T-BET expression. This study therefore identifies an intestinal T cell subset initiating cancer. |
