| Obsolete | false |
| description | A CD8 T cell characterized by high expression of Granzyme K (GZMK). This cell is enriched in both inflamed tissues, such as synovial tissue in rheumatoid arthritis and respiratory tissues during COVID-19, as well as non-inflamed tissues like the gut and kidneys. Unlike highly cytotoxic GZMB+ CD8+ T cell, GZMK+ CD8+ T cell exhibits lower direct cytotoxic potential, and is involved in producing pro-inflammatory cytokines such as IFN-γ and TNF-α. |
