| First Author | Hilgers J | Year | 1984 |
| Journal | Mouse News Lett | Volume | 71 |
| Pages | 14 | Mgi Jnum | J:13976 |
| Mgi Id | MGI:62154 | Citation | Hilgers J (1984) Mtv-19, -20. Mouse News Lett 71:14 |
| abstractText | Full text of MNL contribution: Provirus unit: Mtv-19; EcoRI fragment, kb: 16.7; 13.0; Progenitor strain(1): C: -; S: +; CXS RI strains: 1: +; 2: -; 3: -; 4: +; r: -; 6: -; 7: +; 8: -; 9: +; 10: -; 11: +; 12: -; 13: +; 14: +. Provirus unit: Mtv-20; EcoRI fragment, kb: 10.6; 8.7; Progenitor strain(1): C: -; S: +; CXS RI strains: 1: -; 2: +; 3: -; 4: -; 5: +; 6: -; 7: -; 8: -; 9: -; 10: +; 11: +; 12: +; 13: -; 14: +. (1)C=BALB/cHeA and S=STS/A (See MNL 68, 83-85, 1983) Mtv-19 is a new locus on chromosome 1. Evidence for linkage comes from the SD patterns with chromosome 1 markers. Table 2 shows the results: Locus: Mtv-19; CXS RI strains: 1: S; 2: C; 3: S/X; 4: S; 5: C; 6: C; 7: S; 8: C; 9: S; 10: C/X; 11: S; 12: C; 13: S; 14: S. Mtv-20 is also a new locus. It seems to be located on chromosome 4 in a chromosomal area also rich in Ly genes. Table 3 shows the results: Locus: Mtv-20; CXS RI strains: 1: C; 2: S; 3: C; 4: C; 5: S; 6: C; 7: C; 8: S; 9: C; 10: S; 11: S; 12: C; 13: S; 14: S. Mtv-19 and Mtv-20, present in the STS/A strain, are most likely also present in the related GRS/A strain. The main difference between these two strains is the Mtv-2 locus of the GRS/A not present in the STS/A. Mtv-2 is responsible for the high incidence of mammary tumors in breeding GRS/A females. A manuscript describing these results has been submitted recently: Michalides, R., A. Verstraeten, E.A. Boyse, F.W. Shen and J. Hilgers: Characterization and chromosomal distribution of endogenous mouse mammary tumor viruses of European mouse strains STS/A and GRS/A. |
