| First Author | Peters J | Year | 1980 |
| Journal | Mouse News Lett | Volume | 63 |
| Pages | 17 | Mgi Jnum | J:13860 |
| Mgi Id | MGI:62039 | Citation | Peters J, et al. (1980) Position of Hk-1 on Chromosome 10. Mouse News Lett 63:17 |
| abstractText | Full text of MNL contribution: Linkage tests: 5. Position of Hk-1 on chromosome 10. Hk-1 has been assigned to chromosome 10 using the technique of somatic cell hybridization. (Lalley et al. 1978 Nature 274: 160). The discovery of a genetically determined electrophoretic variant of hexokinase-1 has enabled us to determine the position of the gene. 96 mice have been classified for dl, Hk-1 and Slcon from the mating dl Hk-la Slcon/+ Hk-lb + x dl Hk-la Slcon/dl Hk-la Slcon and the results are as follows: 32 dl HK-1A Slcon; 45 + HK-1AB +; 1 dl HK-1B +; 9 dl HK-1A +; 9 + HK-1B Slcon. The gene order, with RF's is dl-1.0 +/- 1.0-Hk-1-18.8 +/- 4.0-Slcon. 66 mice have been typed for v, HK-1 and gr from the cross v Hk-la gr/+ Hk-1b + x v Hk-la gr/v Hk-la gr giving the following results: 17 v HK-1A gr; 38 + HK-1AB + 1 v HK-1AB gr; 1 + HK-1A gr; 3 v HK-1A +; 6 + HK-1AB gr. The gene order, with RF's is v-3.0 +/- 2.0-Hk-1-13.6 +/- 4.2-gr. Thus Hk-1 is closely linked to dl and the probable gene order is v-dl-Hk-1-gr-Slcon. (Peters, Andrews and Beechey) |
