| First Author | Jockusch H | Year | 1990 |
| Journal | Mouse Genome | Volume | 86 |
| Pages | 216 | Mgi Jnum | J:18491 |
| Mgi Id | MGI:66773 | Citation | Jockusch H, et al. (1990) Close linkage of the myotonia gene, adr, to Hox 1.1 on Chr 6. Mouse Genome 86:216 |
| abstractText | Full text of Mouse Genome contribution: LINKAGE DATA: Close linkage of the myotonia gene, adr, to Hox 1.1 on Chr 6. H. Jockusch, S. Schenk & M. Gronemeir. Davisson et al. (1989 MNL 83, 167) have reported a linkage of about 23 cM between adr and wa-1 on Chr 6. and because no linkage was found between adr and the distal marker Ldr-1 (Schenk & Jockusch 1989 MNL 83, 150) the adr locus was placed between wa-1 and the centromere. For a more detailed mapping of adr, a backcross (A2G adr/+ x SEG) x A2G adr/+ (SEG is a substrain of Mus spretus, kindly provided by Dr. Otto von Deimling, Freiburg) was set up. Using the Hox 1-B 2.8 probe of the Hox 1.1 gene (cf. Bucan et al. 1986 EMBO J 5, 2899-2905), cosegregation of the domesticus Hind III fragment (fragment length 9.5 kb vs. 16 kb for Mus spretus) with the ADR phenotype was studied. Twenty three out of 24 ADR (adr/adr) mice investigated so far were homozygous for the 9.5 kb fragment. This result indicated a 4.2 +/- 4.1 (S.D.) linkage between adr and Hox 1.1 on Chr 6 and provided further evidence, apart from non-complementation, for the allelism of adr and mto. If adr were homologous to Becker's myotonia in man, the latter would be expected to map fairly close to the centromere of human Chr 7. (Hox 1-B 2.8 probe kindly provided by A. Puschel & P. Gruss, Gottingen) |
