| First Author | Eicher EM | Year | 1968 |
| Journal | Mouse News Lett | Volume | 39 |
| Pages | 34 | Mgi Jnum | J:20217 |
| Mgi Id | MGI:68325 | Citation | Eicher EM (1968) The fd translocation and ruby-eye-2. Mouse News Lett 39:34 |
| abstractText | Full text of MNL contribution: Research News: The fd translocation and ruby-eye-2. The ruby-eye mutation (ru-2) described by Dr. Lilly (MNL 34:14) has been further mapped in relatlon to llnkage group I. The order is c - p - ru-2. We are in the processof determining the exact p - ru-2 distance. The ru-2 gene has been mapped in relation to Cattanach's translocation. The wild type allele has been translocated to the Xfd chromosome. Type II males (fd/Y; +/ru-2/ru-2) show an intermediate color between wild type and ruby fur. Type II females (fd/+; ru-2/ru-2) show mosaicism for the intermediate color and ru-2 color. Type I males (fd/Y; ru-2/Df) and females (fd/+; ru-2/Df) do not show any effect of the ru-2 allele. It is unknown whether the lack of any expression of ru-2 in Type I females may be the result of ru-2/Df cells being lethal or that a single dose of ru-2 cannot express the mutant phenotype. However fd/+; p ru-2/Df (Type I females) do express mosaicism for p. Females which are fd/+; p ru-2/p ru-2 express the following mosaic phenotype: intermediate color, p ru-2, and ru-2, this is strong evidence that the +ru-2 allele in the Xfd chromosome can be inactivated without the +p allele. This implies that the inactivation of the autosome I piece in the Xfd chromosome proceeds from both sides of X-chromosomal material. |
