| First Author | Naylor SL | Year | 1989 |
| Journal | Cytogenet Cell Genet | Volume | 51 |
| Pages | 1051 (Abstr.) | Mgi Jnum | J:12501 |
| Mgi Id | MGI:60746 | Citation | Naylor SL, et al. (1989) The progesterone receptor gene is on mouse Chromosome 9. Cytogenet Cell Genet 51:1051 (Abstr.) |
| abstractText | Full text of Abstract: Abstracts of workshop presentations. The progesterone receptor gene is on mouse chromosome 9. (A2135) SL Naylor1, D Helen-Davis1, MR Hughes2, B O'Malley2, PA Lalley3; 1University of Texas Health Science Center at San Antonio; 2Baylor College of Medicine, Houston, TX; 3Wayne State University, Detroit, MI. The progesterone receptor (PGR) gene is located on the long arm of human chromosome 11. This is also the location of INT2, an oncogene insertion site. To explore whether there is homology between INT2 and PGR, we mapped PGR in the mouse. HindIII digest of mouse DNA yielded a single 3.9 Kb fragment hybridizing to hPR54, a human cDNA clone originating from the middle of the progesterone receptor mRNA. Analysis of 12 mouse-Chinese hamster hybrids indicated that the mouse PGR is located on chromosome 9, not chromosome 7, the site of the mouse INT2 locus. There is a large homologous region between human chromosome 11 in the region q13-q22 and mouse chromosome 9. It would appear that the PGR locus is a part of this conserved block of genes. |
