| First Author | Baumann H | Year | 1983 |
| Journal | Mouse News Lett | Volume | 69 |
| Pages | 48 | Mgi Jnum | J:23403 |
| Mgi Id | MGI:71311 | Citation | Baumann H, et al. (1983) The acute pase response in the liver of inbred and wild mice. Mouse News Lett 69:48 |
| abstractText | Full text of MNL contribution: We have examined changes in translatable liver mRNAs during the acute phase response in several inbred mouse strains. Induction of mRNAs for the known acute phase reactants serum amyloid A (SAA), hemopexin, haptoglobin, and a1-acid glycoprotein (AGP) was observed. Two forms of a1-acid glycoprotein, termed AGP-1 and AGP-2, were found in all mice and appear to derive from closely related mRNAs. Polymorphism in the structure of AGP-1 among strains was used to map the structural gene, Agp-1, to chromosome 4 near the b locus. Structural variation for SAA enabled mapping its structural gene, Saa,* to chromosome 7, near Gpi-1. A wild-derived population of mice, Mus spretus, contains several variations of interest, including structural variations in many acute phase proteins and a putative regulatory variation specific to AGP-1. Further analysis of these genetic variants should provide novel insights into the acute phase response and the factors that mediate it. |
