| First Author | Wilson CM | Year | 1983 |
| Journal | Mouse News Lett | Volume | 69 |
| Pages | 53-54 | Mgi Jnum | J:13954 |
| Mgi Id | MGI:62132 | Citation | Wilson CM (1983) Nomenclature for renin genes. Mouse News Lett 69:53-54 |
| abstractText | Full text of MNL contribution: Research News: Several groups have now obtained evidence that inbred strains of mice with low levels of submandibular (submaxillary) gland (SMG) rennin carry a single renin structural gene while strains that have high levels of SMG renin carry two genes. (Piccini, et al.. (1982) Cell 30, 205-213, Panthier, et al.. (1982) EMBO Journal 1, 1417-1421 and Mullins, et al. (1982) EMBO Journal 1, 1461-1466). Piccini and coworkers have mapped both genes to the same region of mouse Chromosome 1 as Ren (formerly Rnr) a locus that determines rennin activity, thermolability, and immunoreactivity. These data suggest that mouse strains originally classified as Rnrs on the basis of renin concentration (Wilson, et al. (1981) Biochem. Genetics 19, 509-523) carry duplicated genes that determine the structure of different renin isoenzymes whereas mice originally classified as Rnrb carry only one renin structural gene. The gene carried by Rnrb type mice appears to be held in common by many inbred strains. Unfortunately, there is considerable variation in terminology currently used by workers who are investigating mouse renin genes. In addition, terms in the literature do not conform to the guidelines established by the Committee on Standardized Nomenclature for Mice. I would like to propose the adoption of the following nomenclature. The gene apparently held in common by inbred strains shall be symbolized Ren-1 and the putative duplicated gene shall be symbolized Ren-2. The symbol Ren-1 is assigned to the gene held in common because current information is compatible with the hypothesis that this gene is expressed in the kidney and, therefore, determines the structure of the physiologically important isoenzyme. When and if additional rennin structural loci are identified they can be symbolized Ren-3, etc. In this system, alleles at the Ren-2 locus are designated Ren-2s (for the duplicated gene carried by type strain SWR/J and other strains with high SMG renin levels) and Ren-2n (indicating a null allele in strains such as C57BL/6.J that apparently do not carry the Ren-2 gene). So far all strains appear to carry the same allele at Ren-1, designated Ren-la. The relationship of the proposed nomenclature to that found in the literature is as follows: SMG RENIN ACTIVITY: Low, thermostable; High, thermolabile; SMG RENIN mRNA: Low; High; RENIN GENE COPIES: One; Two; PROPOSED GENE AND ALLELE SYMBOLS: Ren-1a, Ren-2n; Ren-1a, Ren-2s; NOMENCLATURE FOUND IN THE LITERATURE: Rnrb; Rnrs; Wilson, et al.. (1981) Biochem. Genetics 19, 509-523; Ren-2, Ren-1n; Ren-2, Ren-1s; Wilson and Taylor (1982) J. Biol. Chem. 257, 217-223; Common; Common, Duplicated; Piccini, et al. (1982) Cell 30, 205-213; Ren-A, Ren-B; Mullins, et al. (1982) EMBO J. 1, 1461-1466; Rn-1; Rn-1, Rn-2; Panthier, et al. (1982) EMBO J. 1, 1417-1421. |
