| First Author | Cattanach BM | Year | 1988 |
| Journal | Mouse News Lett | Volume | 80 |
| Pages | 160 | Mgi Jnum | J:14272 |
| Mgi Id | MGI:62443 | Citation | Cattanach BM (1988) Linkage of Hq and Movbr. Mouse News Lett 80:160 |
| abstractText | Full text of MNL contribution: 3. Linkaae of Hq and Mo<vbr>. The two X-linked genes Hq and Mo<vbr> have recently been combined in a single stock and maintained both in the coupling and repulsion phases in crosses with (C3H/HeH x 101/H F>l<) males. This has incidentally generated linkage data which warrant publication in view of the current specific interests in mapping the X chromosome (Mouse Gene Mapping Workshop, MNL 79:55-85, 1987). Phenotypic classifications were made at 10 days, as well as at weaning (20 days), so that Hq males could be classified for Mo<vbr> before they lost their coats. Some difficulty was encountered in identifying Hq in Mo<vbr>+ females but breeding tests suggested that misclassifications were in fact quite rare. Coupling phase crosses produced 96 HqMo<vbr>/++ females, 148 +,+/++ females, 47 HqMo<vbr> males, 130 ++/Y males, 43 Hq +/++ females, 24 +Mo<vbr>/++ females, 39 Hq+/Y males and 38 +Mo<vbr>/Y males. It is evident that the combination of Hq and Mo<vbr> reduces viability both in females and males. However, when allowance was made for this statistically the Hq-Mo<vbr> RF was 20.86 + 1.69%. Repulsion phase crosses produced 69 Hq +/++ females, 54 +Mo<vbr>/++ females, 48 Hq+/Y males, 61 +Mo<vbr>/Y males, 14 HqMo<vbr>/++ females, 23 ++/++ females, 10 HqMo<vbr>/Y males and 16 ++/Y males. Again, there was a shortage of progeny carrying the two markers but when allowance was made for the inviability problems in this cross the RF was calculated to be 25.29 +/- 3.26. The two sets of data were not significantly different ( x 2/3 = 3.81; P = 0.28). When pooled the overall Hq-Mo<vbr> RF was 22.73 +/- 1.41%. The result accords quite well with that indicated on the current Davisson and Roderick linkage map (MNL 79:9). (Cattanach). |
