| First Author | Mattei MG | Year | 1989 |
| Journal | Cytogenet Cell Genet | Volume | 51 |
| Pages | 1041 (Abstr.) | Mgi Jnum | J:12498 |
| Mgi Id | MGI:60743 | Citation | Mattei MG, et al. (1989) Localization of the antiporter gene (APNH) and chromosomal segment homology between human 1p, mouse 4 and Chinese hamster 2q. Cytogenet Cell Genet 51:1041 (Abstr.) |
| abstractText | Full text of Abstract: Localization of the antiporter gene (APNH) and chromosomal homology between human lp, mouse 4 and chinese hamster 2q. (A2656). M-G Mattei1, M Galloni1, C Sardet2, A Franchi2, L Counillon2, E Passage1, J Pouyssegur2. 1INSERM U.242 & Centre de Genetique Medicale, Hopital d'Enfants de la Timone, Marseille; 2Centre de Biochimie, CNRS, Parc Valrose, Nice. The Na4/H4 antiporter is a ubiquitous membrane-bound enzyme involved in pH regulation of vertebrate cells. We previously mapped this gene by in situ hybridization of a genomic probe to human 1p35-lp36.l bands (HGM9; Cytogenet. Cell Genet. 48:6-8, 1988). By in situ chromosomal hybridization of a human cDNA probe, we map the antiporter gene to the distal part of mouse chromosome 4 (4D3-4E) and to the chinese hamster chromosome 2 long arm (telomeric band). These localizations confirm the conserved homology between the distal 1p, the mouse distal 4 and the chinese hamster distal 2q, already suggested by the mapping of four other genes: the 6 Phosphogluconate dehydrogenase (PGD), the Enolase-1 (ENO 1), the Adenylate kinase-2, mitochondria1 (AK 2), the phosphogluconase 2 (PGM 1) (HGM9: Report of the Committee on Comparative Mapping, Lalley et al.). |
