| First Author | Adler ID | Year | 1987 |
| Journal | Mouse News Lett | Volume | 77 |
| Pages | 139-42 | Mgi Jnum | J:17647 |
| Mgi Id | MGI:65680 | Citation | Adler ID, et al. (1987) Seventeen stocks of mice with reciprocal or Robertsonian translocations. Mouse News Lett 77:139-42 |
| abstractText | Full text of MNL contribution: Seventeen stocks of mice with reciprocal or Robertsonian translocations. During the past ten years heritable translocation tests were performed to determine the frequencies of viable chromosomal aberrations induced in male mouse germ cells by mutagen treatment (Adler, Biol. Zentralblatt 97, 441-451, 1978; Adler, Terat., Carcin., Mutagen. 1, 75-86, 1980; Adler et al., Mutat. Res. 74, 223, 1980; Adler et al, Mutat. Res. 130, 175-176, 1984). Table 1 gives the origin of the various translocation stocks. Ten of the autosomal reciprocal translocations were experimentally derived, ie T(1;10), T(4;19), T(5;13), T(6;8), T(6;13), T(7;13), T(8;10), T(9;11), T(9;17) and T(14;18). One occurred in the control group, ie T(5;15). One was identified retrospectively to have been preexisting, ie T(10;13), because two carriers in one experimental group showed a translocation with identical break points and their sires were brothers. Four translocations involving the X-chromosome and chromosome 7 occurred in specific locus experiments as variegated females (Ehling and Neuhauser-Klaus, in Problems in Chemical Mutagenesis, Y. Tazima et al, eds., Kokusaibunken Printing Co., Ltd., Tokyo, pp. 15-25, 1984). Two Robertsonian translocations were also found, Rb(10.14) in an experimental group and Rb(X.2) as the son of the female T(5;13). The Rb(X.2) is the first recovered Robertsonian translocation involving the X-chromosome. Both Robertsonian translocations were made homozygous. All other translocations exist as heterozygous stocks. Extensive effort with T(5;15) yielfrf onr homoxygous female among 56 progeny of heterozygous crosses. The translocations T(4;9), T(6;8), T(10;13) and T(5;15), the Robertsonian translocation Rb(10.14) and the two X-7 translocations T1Neu and T2Neu have already been described (MNL 71:38-40). The chromosomes involved and the tentative break points were identified by trypsin-ASG banding of bone marrow preparations. Table 2 gives the location of the breaks for the reciprocal translocation stocks along with the mean litter sizes of the heterozygous carriers. The multivalent frequencies in first meiotic divisions of spermatocytes, the ratio of chain to ring quadrivalents and the frequencies of carriers among the male progeny are also included. Two stocks have recently been lost, ie T(4;19) and T(14;18). Two of the X;7 translocations (T1Neu and T2Neu) derived from different experiments showed identical break points but they are not assumed to have been preexisting since no relation of ancestors could be traced and the male carriers proved to be sterile. The fourth X;7 translocation stock, ie. Is(7;InX), carries a complex rearrangement with an interstitial deletion of chromosome 7 inserted into an inverted segment of the X-chromosome thereby transferring the pink eyed (p) locus to the X. The balanced (47/194; 24%) and unbalanced progeny (92/194; 47%) of this stock are viable and fertile. (Adler, Neuhauser-Klaus) |
