| First Author | Hsieh CL | Year | 1991 |
| Journal | Mamm Genome | Volume | 1 |
| Pages | S522 (Abstr.) | Mgi Jnum | J:24085 |
| Mgi Id | MGI:71846 | Citation | Hsieh CL, et al. (1991) Assignment of glucose transporter genes to mouse Chromosomes 4 (Glut-1) and 11 (Glut-4). Mamm Genome 1:S522 (Abstr.) |
| abstractText | Full text of Abstract: 38. ASSIGNMENT OF GLUCOSE TRANSPORTER GENES TO MOUSE CHROMOSOMES 4 (Glut-1) AND 11 (Glut-4). C.-L. Hsieh1, M.J. Birnbaum2 and U. Francke1,3. 1Howard Hughes Medical Inst., Stanford CA, 2Dept. Cell. Molec. Physiology, Harvard Medical School, Boston MA, 3Depts. Genetics & Pediatrics, Stanford University Medical School, Stanford CA. Glucose transport across mammalian cell membranes is mediated by a family of structurally related proteins encoded by distinct genes that are expressed and regulated in a tissue-specific manner. By analyzing rodent x mouse and rodent x human somatic cell hybrid panels with a rat cDNA clone for the erythrocyte/brain type (GLUT1) (Birnbaum et al., PNAS 83:5784, 1986), we have mapped the Glut-1 locus to MMU4 and have confirmed the human GLUT1 gene on chromosome 1p32-p22.1 (previous assignment to 1p35-p31.3, Shows et al., Diabetes 36:546, 1987). GLUT4 encodes an insulin-responsive glucose transporter. A rat CDNA identified by screening a rat skeletal muscle CDNA library at low stringency with a rat GLUT1 cDNA (Birnbaum, Cell 57:305, 1989) was used as hybridization probe on somatic cell hybrid panels and RI strains. The human GLUT4 gene was mapped to HSA17, in agreement with localization to 17p13 (Bell et al., Diabetes 38:1072, 1989). The mouse Glut-4 locus was assigned to MMU11. |
