| First Author | Cattanach BM | Year | 1997 |
| Journal | Mouse Genome | Volume | 95 |
| Pages | 485 | Mgi Jnum | J:51116 |
| Mgi Id | MGI:1314613 | Citation | Cattanach BM (1997) A further chromosome 13 deletion. Mouse Genome 95:485 |
| abstractText | Full text of Mouse Genome contribution: Research News: 2. A further chromosome 13 deletion. The original animal was detected in a combined chemical radiation study through growth retardation. As in the case of most of the previously described large deletions (Cattanach et a1 Nature Genetics 3:56-61, 1993; Cattanach et a1 Proc 10th ICCR, Vol 2, pp 531-534, 1996) this was evident both at birth and weaning, additionally the mouse also expressed a distinct domed head phenotype. Both characteristics were inherited but few affected animals were seen at birth and the majority failed to survive to weaning. Impairment therefore appears to be severe. A further characteristic, which was not immediately recognised, was the presence of a tiny nub resembling a foot pad located on the side of the hallux of each rear foot. The exact nature of this protrusion has not yet been established. G-band analysis showed a large deletion involving most of the pale staining band B of Chr 13 which reduced the overall length of the chromosome by about 7%. The new deletion therefore lies immediately proximal to Del(13)52H, suggesting that a significant proportion of central Chr 13 contains genes which are haplo sufficient. The deletion has been named Del(13)81H. (Cattanach, Rasberry, Clements and Evans) |
