| First Author | Cook SA | Year | 1993 |
| Journal | Mouse Genome | Volume | 91 |
| Pages | 312 | Mgi Jnum | J:16800 |
| Mgi Id | MGI:64861 | Citation | Cook SA, et al. (1993) Dominant brown. Mouse Genome 91:312 |
| abstractText | Full text of Mouse Genome contribution: Research News: 2. Dominant brown. Dominant brown (Dbr) is a probable re-mutation at the underwhite (uw) locus on proximal Chromosome 15. The gene symbol for dominant brown has been officially changed to Uwdbr. A linkage backcross between C57BL/J-Dbr/+ and Rb(5.15)3Bnr yielded no recombinants from 38 progeny. To determine if dominant brown was located on Chromosome 5 or Chromosome 15, a backcross with Mus musculus castaneous (CAST/Ei) yielded 31/104 = 29.8 +/- 6.3 with glutamate pyruvate transaminase (Gpt-1) on Chromosome 15. No linkage (50% recombination) was found with glycerophosphate dehydrogenase (Gdc-1) on distal Chromosome 15 or with phosphoglucose mutase (Pgrn-1) on Chromosome 5. Dominant brown is a semi-dominant mutation. Heterozygotes appear dark brown and homozygotes are light beige resembling uw/uw. An allele test between a homozygous Dbr/Dbr and a homozygous uw/uw yielded all "uw/uw-like" mice (no dark brown mice or Dbr/+) from a total of 33 progeny. An intercross between two mice doubly heterozygous for Dbr and uw (Dbr+/uw+) yielded a total of 161/161 "uw/uw-like" progeny. There were no dark brown mice (Dbr/+) nor any cross-overs yielding black-coated mice (uw/+ or +/+). Uwdbr is available on the C57BL/J genetic background. The recessive uw allele is available both on the C57BL/J background and in a linkage testing strain: STOCK uw.Gpt-1b.Gdc-1d.bt2J. (Susan A. Cook and Muriel T. Davisson) |
