| First Author | Sugisaki T | Year | 1992 |
| Journal | Neurochem Res | Volume | 17 |
| Issue | 10 | Pages | 1037-40 |
| PubMed ID | 1508304 | Mgi Jnum | J:3079 |
| Mgi Id | MGI:51594 | Doi | 10.1007/BF00966833 |
| Citation | Sugisaki T, et al. (1992) Microcephalic cerebrum with hypomyelination in the congenital goiter mouse (cog). Neurochem Res 17(10):1037-40 |
| abstractText | 2',3'-Cyclic nucleotide 3'-phosphohydrolase activity in the cerebrum of the congenital goiter mouse (cog/cog) is reduced in comparison with the normal heterozygote (cog/+). The weight of the cog/cog cerebrum and cerebellum were significantly less than those of the normal controls, 89.0% less for the cerebrum, and 81.1% less for the cerebellum. However, no differences were observed with regard to DNA and RNA content and the RNA/DNA ratio. The results of this study indicate that hypomyelination in the congenital goiter mouse is restricted to the cerebrum, and is not related to arrested glial proliferation. |
