| First Author | Urbanska M | Year | 2018 |
| Journal | Mol Neurobiol | Volume | 55 |
| Issue | 7 | Pages | 6050-6062 |
| PubMed ID | 29143288 | Mgi Jnum | J:367331 |
| Mgi Id | MGI:6296019 | Doi | 10.1007/s12035-017-0823-9 |
| Citation | Urbanska M, et al. (2018) GSK3beta Controls mTOR and Prosurvival Signaling in Neurons. Mol Neurobiol 55(7):6050-6062 |
| abstractText | Glycogen synthase kinases-3beta (GSK3beta) is a key regulator of cell homeostasis. In neurons, GSK3beta contributes to control of neuronal transmission and plasticity. Despite extensive studies in non-neuronal cells, crosstalk between GSK3beta and other signaling pathways remains not well defined in neurons. In the present study, we report that GSK3beta positively affected the activity of effectors of mammalian target of rapamycin complex 1 (mTORC1) and complex 2 (mTORC2), in mature neurons in vitro and in vivo. GSK3beta also promoted prosurvival signaling and attenuated kainic acid-induced apoptosis. Our study identified GSK3beta as a positive regulator of prosurvival signaling, including the mTOR pathway, and indicates the possible neuroprotective role of GSK3beta in models of pharmacologically induced excitotoxicity. |
