| First Author | McHugh TJ | Year | 1996 |
| Journal | Cell | Volume | 87 |
| Issue | 7 | Pages | 1339-49 |
| PubMed ID | 8980239 | Mgi Jnum | J:37456 |
| Mgi Id | MGI:84849 | Doi | 10.1016/s0092-8674(00)81828-0 |
| Citation | McHugh TJ, et al. (1996) Impaired hippocampal representation of space in CA1-specific NMDAR1 knockout mice. Cell 87(7):1339-49 |
| abstractText | To investigate the role of synaptic plasticity in the place-specific firing of the hippocampus, we have applied multiple electrode recording techniques to freely behaving mice with a CA1 pyramidal cell-specific knockout of the NMDAR1 gene. We have discovered that although the CA1 pyramidal cells of these mice retain place-related activity, there is a significant decrease in the spatial specificity of individual place fields. We have also found a striking deficit in the coordinated firing of pairs of neurons tuned to similar spatial locations. Pairs have uncorrelated firing even if their fields overlap. These results demonstrate that NMDA receptor-mediated synaptic plasticity is necessary for the proper representation of space in the CA1 region of the hippocampus. |
