| First Author | Leduc C | Year | 2014 |
| Journal | Cell Cycle | Volume | 13 |
| Issue | 10 | Pages | 1583-9 |
| PubMed ID | 24675885 | Mgi Jnum | J:270127 |
| Mgi Id | MGI:6276427 | Doi | 10.4161/cc.28560 |
| Citation | Leduc C, et al. (2014) Tissue-specific inactivation of HAT cofactor TRRAP reveals its essential role in B cells. Cell Cycle 13(10):1583-9 |
| abstractText | The transformation/transcription domain-associated protein (TRRAP) is a common component of many histone acetyltransferase (HAT) complexes. Targeted-deletion of the Trrap gene led to early embryonic lethality and revealed a critical function of TRRAP in cell proliferation. Here, we investigate the function of TRRAP in murine B cells. To this end, we ablated Trrap gene in a B cell-restricted manner and studied its impact on B-cell development and proliferation, a pre-requisite for class switch recombination (CSR), the process that allows IgM-expressing B lymphocytes to switch to the expression of IgG, IgE, or IgA isotypes. We show that TRRAP deficiency impairs B-cell development but does not directly affect CSR. Instead, cells induced to proliferate undergo apoptosis. Our findings demonstrate a central and general role of TRRAP in cell proliferation. |
