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Publication : New insights of growth hormone (GH) actions from tissue-specific GH receptor knockouts in mice.

First Author  List EO Year  2019
Journal  Arch Endocrinol Metab Volume  63
Issue  6 Pages  557-567
PubMed ID  31939480 Mgi Jnum  J:373607
Mgi Id  MGI:6761695 Doi  10.20945/2359-3997000000185
Citation  List EO, et al. (2019) New insights of growth hormone (GH) actions from tissue-specific GH receptor knockouts in mice. Arch Endocrinol Metab 63(6):557-567
abstractText  In order to provide new insights into the various activities of GH in specific tissues, recent advances have allowed for the generation of tissue-specific GHR knockout mice. To date, 21 distinct tissue-specific mouse lines have been created and reported in 28 publications. Targeted tissues include liver, muscle, fat, brain, bone, heart, intestine, macrophage, pancreatic beta cells, hematopoietic stem cells, and multi-tissue "global". In this review, we provide a brief history and description of the 21 tissue-specific GHR knockout mouse lines. Arch Endocrinol Metab. 2019;63(6):557-67.
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