| First Author | Hendricks WD | Year | 2026 |
| Journal | Neuron | Volume | 114 |
| Issue | 7 | Pages | 1257-1268.e5 |
| PubMed ID | 41702398 | Mgi Jnum | J:389387 |
| Mgi Id | MGI:8319793 | Doi | 10.1016/j.neuron.2025.12.021 |
| Citation | Hendricks WD, et al. (2026) Feature-tuned synaptic inputs to somatostatin interneurons drive context-dependent processing. Neuron 114(7):1257-1268.e5 |
| abstractText | Mapping neural computation onto the functional microarchitecture of sensory circuits is essential for understanding how brain circuits transform input signals into coherent percepts. Many higher-order perceptual processes emerge in the cortex, yet relatively little is known about how specific connectivity motifs give rise to these computations. To address this challenge, we combined single-cell and population-level physiological recordings and perturbation methods to map a context-dependent cortical computation onto the synaptic microarchitecture of the mouse primary visual cortex (V1). We demonstrate a precise pattern of synaptic connectivity from cortical pyramidal cells (PCs) to somatostatin (SST) inhibitory interneurons that mediates context-driven figure/ground modulation in V1. Through a like-to-like connectivity rule from PCs to SSTs, this circuit explains SSTs' visual encoding properties and their resulting impact on contextual modulation in V1. These findings reveal key synaptic and circuit mechanisms that may underlie the earliest stages of scene segmentation in the visual cortex. |
