| First Author | Pedro MP | Year | 2020 |
| Journal | J Invest Dermatol | Volume | 140 |
| Issue | 6 | Pages | 1195-1203.e3 |
| PubMed ID | 31707029 | Mgi Jnum | J:376208 |
| Mgi Id | MGI:8269053 | Doi | 10.1016/j.jid.2019.10.012 |
| Citation | Pedro MP, et al. (2020) Activation of G-Protein Coupled Receptor-Galphai Signaling Increases Keratinocyte Proliferation and Reduces Differentiation, Leading to Epidermal Hyperplasia. J Invest Dermatol 140(6):1195-1203.e3 |
| abstractText | G-protein coupled receptors (GPCRs) and their associated heterotrimeric G proteins impinge on pathways that control epithelial cell self-renewal and differentiation. Although it is known that Galphas protein signaling regulates skin homeostasis in vivo, the role of GPCR-coupled Galphai proteins in the skin is unclear. Here, by using a chemogenetic approach, we demonstrate that GPCR-Galphai activation can regulate keratinocyte proliferation and differentiation and that overactivation of Galphai-signaling in the basal compartment of the mouse skin can lead to epidermal hyperplasia. Our results expand our understanding of the role of GPCR-cAMP signaling in skin homeostasis and reveal overlapping and divergent roles of the cAMP-regulating heterotrimeric Galphas and Galphai proteins in keratinocytes. |
